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Sulphonamide inhibition studies of the β-carbonic anhydrase GsaCAβ present in the salmon platyhelminth parasite Gyrodactylus salaris

A β-class carbonic anhydrase (CA, EC 4.2.1.1) present in the genome of the Monogenean platyhelminth Gyrodactylus salaris, a fish parasite, GsaCAβ, has been investigated for its inhibitory effects with a panel of sulphonamides and sulfamates, some of which in clinical use. Several effective GsaCAβ in...

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Principais autores: Ashok Aspatwar, Alessandro Bonardi, Heidi Aisala, Ksenia Zueva, Craig R Primmer, Jaakko Lumme, Seppo Parkkila, Claudiu T. Supuran
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2023-12-01
Serier:Journal of Enzyme Inhibition and Medicinal Chemistry
Fag:
Carbonic anhydrase
Gyrodactylus salaris
kinetics
sulphonamide inhibitors
sulfamate
Online adgang:https://www.tandfonline.com/doi/10.1080/14756366.2023.2167988
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