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Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors

Human thymidylate synthase (hTS) is pivotal for cell survival and proliferation, indeed it provides the only synthetic source of dTMP, required for DNA biosynthesis. hTS represents a validated target for anticancer chemotherapy. However, active site-targeting drugs towards hTS have limitations conne...

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Principais autores: Cecilia Pozzi, Stefania Ferrari, Rosaria Luciani, Maria Paola Costi, Stefano Mangani
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-04-01
coleção:Molecules
Assuntos:
human thymidylate synthase
interface variant
active conformation
tethering approach
X-ray crystallography
anticancer drugs
Acesso em linha:https://www.mdpi.com/1420-3049/24/7/1362
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