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Long-term stability of clinical-grade lentiviral vectors for cell therapy

The use of lentiviral vectors in cell and gene therapy is steadily increasing, both in commercial and investigational therapies. Although existing data increasingly support the usefulness and safety of clinical-grade lentiviral vectors used in cell manufacturing, comprehensive studies specifically a...

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Principais autores: Julie K. Jadlowsky, Rachel Leskowitz, Stephen McKenna, Jayashree Karar, Yujie Ma, Anlan Dai, Gabriela Plesa, Fang Chen, Kathleen Alexander, Jennifer Petrella, Nan Gong, Wei-Ting Hwang, Olivia Farrelly, Julie Barber-Rotenberg, Shannon Christensen, Vanessa E. Gonzalez, Anne Chew, Joseph A. Fraietta, Carl H. June
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-03-01
coleção:Molecular Therapy: Methods & Clinical Development
Assuntos:
titer stability
potency
transduction efficiency
lentiviral vector
cell therapy
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2329050124000020
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