Peripheral B cell immune dysregulation genetically contributes to stage-dependent neuroinflammation and identifies priority therapeutic targets in Parkinson’s disease: a computational integration of Mendelian randomization and single-cell transcriptomics
BackgroundParkinson’s disease (PD) lacks reliable peripheral biomarkers and disease-modifying therapies. Although peripheral B-cell alterations have been observed in PD, whether genetically predicted B-cell gene expression contributes to PD risk and can nominate candidate therapeutic targets remains...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2026-06-01
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| coleção: | Frontiers in Medicine |
| Assuntos: | |
| Acesso em linha: | https://www.frontiersin.org/articles/10.3389/fmed.2026.1853077/full |
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