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Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2

ABSTRACT Globally, more antimicrobials are used in food-producing animals than in humans, and the extensive use of medically important human antimicrobials poses a significant public health threat in the face of rising antimicrobial resistance (AMR). The development of novel ionophores, a class of a...

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Principais autores: Nichaela Harbison-Price, Scott A. Ferguson, Adam Heikal, George Taiaroa, Kiel Hards, Yoshio Nakatani, David Rennison, Margaret A. Brimble, Ibrahim M. El-Deeb, Lisa Bohlmann, Christopher A. McDevitt, Mark von Itzstein, Mark J. Walker, Gregory M. Cook
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2020-04-01
Series:mSphere
Assuntos:
antimicrobial resistance
PBT2
zinc
manganese
ionophore
metal ion homeostasis
Acceso en liña:https://journals.asm.org/doi/10.1128/mSphere.00157-20
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