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Palmitate-Triggered COX2/PGE2-Related Hyperinflammation in Dual-Stressed PdL Fibroblasts Is Mediated by Repressive H3K27 Trimethylation

The interrelationships between periodontal disease, obesity-related hyperlipidemia and mechanical forces and their modulating effects on the epigenetic profile of periodontal ligament (PdL) cells are assumed to be remarkably complex. The PdL serves as a connective tissue between teeth and alveolar b...

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Principais autores: Lisa Schuldt, Michael Reimann, Katrin von Brandenstein, Julia Steinmetz, Annika Döding, Ulrike Schulze-Späte, Collin Jacobs, Judit Symmank
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-03-01
Serier:Cells
Fag:
periodontitis
tooth movement
obesity
palmitic acid
histone modification
inflammation
Online adgang:https://www.mdpi.com/2073-4409/11/6/955
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