Analysis of multiple gene co-expression networks to discover interactions favoring CFTR biogenesis and ΔF508-CFTR rescue

Abstract Background We previously reported that expression of a miR-138 mimic or knockdown of SIN3A in primary cultures of cystic fibrosis (CF) airway epithelia increased ΔF508-CFTR mRNA and protein levels, and partially restored CFTR-dependent chloride transport. Global mRNA transcript profiling in...

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Auteurs principaux:	Matthew D. Strub, Long Gao, Kai Tan, Paul B. McCray
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2021-10-01
Collection:	BMC Medical Genomics
Sujets:	Cystic fibrosis CFTR Transcriptional profiling Network biology Gene modules Gene ontology
Accès en ligne:	https://doi.org/10.1186/s12920-021-01106-7
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