Quantifying the Inhibitory Efficacy of HIV-1 Therapeutic Interfering Particles at a Single CD4 T-Cell Resolution

Efficient control of HIV-1 infection relies on highly active antiretroviral therapy (HAART). However, this therapy is not curative and requires continuous drug administration. Application of HIV-1 defective interfering particles (DIPs), engineered with ablations in key viral protein expressions (e.g...

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Hauptverfasser:	Igor Sazonov, Dmitry Grebennikov, Rostislav Savinkov, Andreas Meyerhans, Gennady Bocharov
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2025-10-01
Schriftenreihe:	Viruses
Schlagworte:	HIV-1 life cycle therapeutic interfering particles mathematical models CD4 T cell inhibitory effect single cell
Online-Zugang:	https://www.mdpi.com/1999-4915/17/10/1378
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