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Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels

Synaptic ribbons are structures made largely of the protein Ribeye that hold synaptic vesicles near release sites in non-spiking cells in some sensory systems. Here, we introduce frameshift mutations in the two zebrafish genes encoding for Ribeye and thus remove Ribeye protein from neuromast hair ce...

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Principais autores: Caixia Lv, William J. Stewart, Otar Akanyeti, Courtney Frederick, Jie Zhu, Joseph Santos-Sacchi, Lavinia Sheets, James C. Liao, David Zenisek
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016-06-01
Serier:Cell Reports
Fag:
hair cell
retina
synaptic ribbon
hearing
vestibular system
exocytosis
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124716306283
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