The medial septum-hippocampus-lateral septum circuitry in spatial memory: linking healthy function to early Alzheimer’s disease and translational opportunities

Abstract Hippocampus (HPC)-associated spatial memory deficits are one of the earliest symptoms of Alzheimer’s disease (AD). Current pharmacological treatments only alleviate the symptoms but do not prevent disease progression. The emergence of neuromodulation technology suggests that specific neural...

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Detalhes bibliográficos

Principais autores:	Yujie Song, Junjun Ni, Hong Qing, Zhenzhen Quan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-09-01
coleção:	Translational Neurodegeneration
Assuntos:	Alzheimer's disease Spatial memory Medial septum–hippocampus–lateral septum neural circuitry Synaptic dysfunction Neuromodulation Glutamate receptors
Acesso em linha:	https://doi.org/10.1186/s40035-025-00511-7
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