Quasi-Irreversible Inhibition of CYP2D6 by Berberine

In our previous study, Hwang-Ryun-Hae-Dok-Tang, which contains berberine (BBR) as a main active ingredient, inhibited cytochrome P450 (CYP) 2D6 in a quasi-irreversible manner. However, no information is available on the detailed mechanism of BBR-induced CYP2D6 inhibition. Thus, the present study aim...

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主要な著者:	Ha Gyeong Kim, Han Sol Lee, Jang Su Jeon, Young Jae Choi, Yeon Jung Choi, So-Yeol Yoo, Eun-yeong Kim, Kiho Lee, InWha Park, MinKyun Na, Han-Jin Park, Seung-Woo Cho, Jong-Hoon Kim, Jae-Young Lee, Sang Kyum Kim
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2020-09-01
シリーズ:	Pharmaceutics
主題:	berberine cytochrome P450 herb-drug interaction metabolite identification drug metabolism
オンライン･アクセス:	https://www.mdpi.com/1999-4923/12/10/916
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