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Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling

Desmoplastic small round cell tumor (DSRCT) is characterized by the t(11;22)(p13;q12) translocation, which fuses the transcriptional regulatory domain of EWSR1 with the DNA-binding domain of WT1, resulting in the oncogenic EWSR1-WT1 fusion protein. The paucity of DSRCT disease models has hampered pr...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Roger S. Smith, Igor Odintsov, Zebing Liu, Allan Jo-Weng Lui, Takuo Hayashi, Morana Vojnic, Yoshiyuki Suehara, Lukas Delasos, Marissa S. Mattar, Julija Hmeljak, Hillary A. Ramirez, Melissa Shaw, Gabrielle Bui, Alifiani B. Hartono, Eric Gladstone, Siddharth Kunte, Heather Magnan, Inna Khodos, Elisa De Stanchina, Michael P. La Quaglia, Jinjuan Yao, Marick Laé, Sean B. Lee, Lee Spraggon, Christine A. Pratilas, Marc Ladanyi, Romel Somwar
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists 2022-01-01
Schriftenreihe:Disease Models & Mechanisms
Schlagworte:
ewsr1-wt1
dsrct pdx
egfr
sarcoma proteomics
Online-Zugang:http://dmm.biologists.org/content/15/1/dmm047621
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