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Predicting disordered regions driving phase separation of proteins under variable salt concentration

We investigate intrinsically disordered regions (IDRs) of phase separating proteins regarding their impact on liquid-liquid phase separation (LLPS) of the full protein. Our theoretical approach uses a mean-field theory that accounts for sequence-dependent electrostatic interactions via a Random Phas...

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Bibliografische Detailangaben
Hauptverfasser: Esteban Meca, Anatol W. Fritsch, Juan M. Iglesias-Artola, Simone Reber, Barbara Wagner
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2023-06-01
Schriftenreihe:Frontiers in Physics
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Online-Zugang:https://www.frontiersin.org/articles/10.3389/fphy.2023.1213304/full
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