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Identification of Closed Linear Epitopes in S1-RBD and S2-HR1/2 of SARS-CoV-2 Spike Protein Able to Induce Neutralizing Abs

SARS-CoV-2 has evolved as several variants. Immunization to boost the Ab response to Spike antigens is effective, but similar vaccines could not enhance Ab efficacy enough. Effective Ab responses against the human ACE2 (hACE2)-mediated infection of the emerging SARS-CoV-2 variants are needed. We ide...

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Principais autores: Yoshihiro Watanabe, Natsuko Hosokawa, Misaki Yoshida, Tomoyuki Miura, Mitsuhiro Kawano
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-01-01
coleção:Vaccines
Assuntos:
Ab-epitope
closed peptide epitope (CPE)-presenting antigen (Ag)
SARS-CoV-2 spike
mutated epitope
universal epitope
sublingual vaccine
Acesso em linha:https://www.mdpi.com/2076-393X/11/2/287
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