T790M mutation sensitizes non-small cell lung cancer cells to radiation via suppressing SPOCK1

Background: Approximately 50% of patients harbor the T790M mutation after developing first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance. Evidence has showed the major treatment failure is local relapses and limited metastases. Several studies have demon...

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Detalhes bibliográficos

Principais autores:	Yasi Xu, Pengjun Zhao, Xiao Xu, Shirong Zhang, Bing Xia, Lucheng Zhu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-07-01
coleção:	Biochemistry and Biophysics Reports
Assuntos:	SPOCK1 Radiation Acquired resistance Non-small cell lung cancer Tyrosine-kinase inhibitor
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2405580824000931
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