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Targeted locus amplification to develop robust patient-specific assays for liquid biopsies in pediatric solid tumors

BackgroundLiquid biopsies combine minimally invasive sample collection with sensitive detection of residual disease. Pediatric malignancies harbor tumor-driving copy number alterations or fusion genes, rather than recurrent point mutations. These regions contain tumor-specific DNA breakpoint sequenc...

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Principais autores: Lieke M. J. van Zogchel, Nathalie S. M. Lak, Nina U. Gelineau, Irina Sergeeva, Ellen Stelloo, Joost Swennenhuis, Harma Feitsma, Max van Min, Erik Splinter, Margit Bleijs, Marian Groot Koerkamp, Willemijn Breunis, Michael Torsten Meister, Waleed Hassan Kholossy, Frank C. P. Holstege, Jan J. Molenaar, Wendy W. J. de Leng, Janine Stutterheim, C. Ellen van der Schoot, Godelieve A. M. Tytgat
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-04-01
coleção:Frontiers in Oncology
Assuntos:
paediatric cancer
neuroblastoma
cell-free DNA (cfDNA)
liquid biopsy
patient-specific ddPCR
TLA
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2023.1124737/full
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