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Polygenic determinants in extremes of high-density lipoprotein cholesterol

HDL cholesterol (HDL-C) remains a superior biochemical predictor of CVD risk, but its genetic basis is incompletely defined. In patients with extreme HDL-C concentrations, we concurrently evaluated the contributions of multiple large- and small-effect genetic variants. In a discovery cohort of 255 u...

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Enregistré dans:
Auteurs principaux: Jacqueline S. Dron, Jian Wang, Cécile Low-Kam, Sumeet A. Khetarpal, John F. Robinson, Adam D. McIntyre, Matthew R. Ban, Henian Cao, David Rhainds, Marie-Pierre Dubé, Daniel J. Rader, Guillaume Lettre, Jean-Claude Tardif, Robert A. Hegele
Format: Artigo
Langue:Inglês
Publié: Elsevier 2017-11-01
Collection:Journal of Lipid Research
Sujets:
genetics
genomics
dyslipidemias
genes in lipid dysfunction
complex trait
rare variants
Accès en ligne:http://www.sciencedirect.com/science/article/pii/S0022227520338062
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