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Q-Rich Yeast Prion [PSI+] Accelerates Aggregation of Transthyretin, a Non-Q-Rich Human Protein

Interactions amongst different amyloid proteins have been proposed as a probable mechanism of aggregation and thus an important risk factor for the onset as well as progression of various neurodegenerative disorders including Alzheimer's, Parkinson's, Huntington's, and Amyotrophic Lateral Sclerosis....

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Main Authors: Meenakshi Verma, Amandeep Girdhar, Basant Patel, Nirmal K. Ganguly, Ritushree Kukreti, Vibha Taneja
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
amyloid aggregation
cross-seeding
transthyretin
Sup35 protein
yeast prion [PSI+]
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00075/full
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