Repurposing harmaline as a novel approach to reverse tmexCD1-toprJ1-mediated tigecycline resistance against klebsiella pneumoniae infections

Abstract Background A novel plasmid-mediated resistance–nodulation–division (RND) efflux pump gene cluster tmexCD1-toprJ1 in Klebsiella pneumoniae tremendously threatens the use of convenient therapeutic options in the post-antibiotic era, including the “last-resort” antibiotic tigecycline. Results...

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Bibliographic Details

Main Authors:	Jindian Yang#, Lei Xu#, Yonglin Zhou, Minhe Cui, Dejun Liu, Jianfeng Wang, Yang Wang, Xuming Deng
Format:	Artigo
Language:	Inglês
Published:	BMC 2024-05-01
Series:	Microbial Cell Factories
Subjects:	Harmaline tmexCD1-toprJ1 Tigecycline Klebsiella pneumoniae
Online Access:	https://doi.org/10.1186/s12934-024-02410-4
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