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A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model

Abstract Background Alzheimer’s disease (AD) and related tauopathies are neurodegenerative diseases that are characterized by the presence of insoluble inclusions of the protein tau within brain neurons and often glia. Tau is normally found associated with axonal microtubules (MTs) in the brain, and...

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Main Authors: Bin Zhang, Yuemang Yao, Anne-Sophie Cornec, Killian Oukoloff, Michael J. James, Pyry Koivula, John Q. Trojanowski, Amos B. Smith, Virginia M.-Y. Lee, Carlo Ballatore, Kurt R. Brunden
Format: Artigo
Language:Inglês
Published: BMC 2018-11-01
Series:Molecular Neurodegeneration
Subjects:
Microtubule
Tauopathy
Therapeutic
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s13024-018-0291-3
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