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Peripheral immune profiling identifies developmental immune displacement into an HLA-DR-low monocyte state in necrotizing enterocolitis

BackgroundNecrotizing enterocolitis (NEC) is a devastating inflammatory disease of prematurity, yet how it reshapes systemic immunity relative to normal postnatal immune maturation remains unclear. We sought to define the peripheral immune architecture of NEC within a developmental framework and to...

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Autori principali: Yihuang Huang, Luyang Hong, Xinhui Guo, Huiyu Chen, Ningxin Luo, Shujuan Li, Junyan Han, Xincheng Cao, Siyuan Jiang, Yun Cao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2026-07-01
Serie:Frontiers in Immunology
Soggetti:
HLA-DR
immune development
mass cytometry
monocytes
necrotizing enterocolitis
preterm infants
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1868823/full
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