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Identification of a family of species-selective complex I inhibitors as potential anthelmintics

Abstract Soil-transmitted helminths (STHs) are major pathogens infecting over a billion people. There are few classes of anthelmintics and there is an urgent need for new drugs. Many STHs use an unusual form of anaerobic metabolism to survive the hypoxic conditions of the host gut. This requires rho...

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Bibliografische Detailangaben
Hauptverfasser: Taylor Davie, Xènia Serrat, Lea Imhof, Jamie Snider, Igor Štagljar, Jennifer Keiser, Hiroyuki Hirano, Nobumoto Watanabe, Hiroyuki Osada, Andrew G. Fraser
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2024-05-01
Schriftenreihe:Nature Communications
Online-Zugang:https://doi.org/10.1038/s41467-024-47331-3
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