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Tumor-directed evolution of VSVΔ51M produces novel viruses with enhanced antitumor efficacy

Oncolytic virotherapy has gained enormous attention and is undergoing extensive research, specifically, the Vesicular Stomatitis Virus (VSV). VSV has been shown to provide a potential tool on which many modifications can be introduced to improve its efficacy. Here we report utilizing a modified VSV...

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Principais autores: Omar A. Albaradie, Abdulaziz Molham Moglan, Yahya Marwan Samman, Fares Fayez Alsayegh, Hussam Mohsen Alharbi, Nada Almarghalani, Khulood Alotaibi, Mohammed M. Jalal, Malik A. Altayar, Nizar H. Saeedi, Hanan A. Niaz, Samer Zakri, Adnan Almuzaini, Feras Kaboha, Saleh Y. Alabbas, Yasmeen A. Albalawi, Abeer Alsofyani, Adrian Pelin, May Abdulaiz Alsayb, Shymaa Damfo, Ahmad Bakur Mahmoud, Almohanad A. Alkayyal
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-05-01
coleção:Frontiers in Molecular Biosciences
Assuntos:
oncolytic virotherapy
personalized therapy
vesicular stomatitis virus
viral evolution
VSVΔ51M
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmolb.2026.1656006/full
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