Exogenous 8-hydroxydeoxyguanosine attenuates doxorubicin-induced cardiotoxicity by decreasing pyroptosis in H9c2 cardiomyocytes

Abstract Doxorubicin (DOX), which is widely used in cancer treatment, can induce cardiomyopathy. One of the main mechanisms whereby DOX induces cardiotoxicity involves pyroptosis through the NLR family pyrin domain containing 3 (NLRP3) inflammasome and gasdermin D (GSDMD). Increased NAPDH oxidase (N...

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Detalhes bibliográficos

Principais autores:	Soyoung Hwang, Se-Hee Kim, Kwai Han Yoo, Myung-Hee Chung, Jin Woo Lee, Kuk Hui Son
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-12-01
coleção:	BMC Molecular and Cell Biology
Assuntos:	Exogenous 8-hydroxydeoxyguanosine Doxorubicin Cardiotoxicity Pyroptosis
Acesso em linha:	https://doi.org/10.1186/s12860-022-00454-1
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