Single-cell sequencing analysis and machine learning model reveal aberrant TIM-3 expression in microglia during Alzheimer’s disease progression

Abstract Background Alzheimer’s disease (AD) is characterized by progressive neurodegeneration and neuroinflammation, with microglial dysfunction playing a pivotal role in its pathogenesis. The specific function of the immune checkpoint molecule TIM-3 (encoded by HAVCR2) in microglia remains unclear...

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Váldodahkkit:	Zongtang Xu, Minshan Chen, Fengchu Liang, Siyuan Song, Jiawen Lei, Xingting Huang, Di Hu, Ling Tang, Pingyi Xu, Lin Lu
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2026-01-01
Ráidu:	Journal of Translational Medicine
Fáttát:	Alzheimer's disease HAVCR2 TIM-3 Microglia Neuroinflammation Molecular subtypes
Liŋkkat:	https://doi.org/10.1186/s12967-025-07621-w
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