Systems metabolic engineering of dual pathways with stage-specific activation for high-level 5-aminolevulinic acid production in Escherichia coli

5-Aminolevulinic acid (5-ALA) is an important non-proteinogenic amino acid with wide applications in agriculture and medicine. To achieve high-level microbial production, this study established a dual-pathway reconstruction strategy in Escherichia coli by integrating the endogenous C5 pathway with a...

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Autores principales:	Yanghao Liu, Changgeng Li, Yu Miao, Zhichao Chen, Tang'en Shi, Ling Ma, Siyu Zhao, Zichen Yu, Lanxiao Li, Qingyang Xu
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	KeAi Communications Co., Ltd. 2026-03-01
Colección:	Synthetic and Systems Biotechnology
Materias:	5-Aminolevulinic acid Systems metabolic engineering Dual-pathway coordination strategy Quorum sensing regulation
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2405805X25001486
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