Development of adenoviral vectors that transduce Purkinje cells and other cerebellar cell-types in the cerebellum of a humanized mouse model

Viral vector gene therapy has immense promise for treating central nervous system (CNS) disorders. Although adeno-associated virus vectors (AAVs) have had success, their small packaging capacity limits their utility to treat the root cause of many CNS disorders. Adenoviral vectors (Ad) have tremendo...

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Váldodahkkit:	Emre Kul, Uchechi Okoroafor, Amanda Dougherty, Lauren Palkovic, Hao Li, Paula Valiño-Ramos, Leah Aberman, Samuel M. Young, Jr.
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Elsevier 2024-06-01
Ráidu:	Molecular Therapy: Methods & Clinical Development
Fáttát:	viral vector gene therapy retrograde transduction helper-dependent adenoviral vector chimeric adenoviral vector cerebellum Purkinje cell
Liŋkkat:	http://www.sciencedirect.com/science/article/pii/S2329050124000597
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