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Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway

The Hippo pathway effectors YAP and TAZ act as nuclear sensors of mechanical signals in response to extracellular matrix (ECM) cues. However, the identity and nature of regulators in the ECM and the precise pathways relaying mechanoresponsive signals into intracellular sensors remain unclear. Here,...

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Principais autores: Sayan Chakraborty, Kizito Njah, Ajaybabu V. Pobbati, Ying Bena Lim, Anandhkumar Raju, Manikandan Lakshmanan, Vinay Tergaonkar, Chwee Teck Lim, Wanjin Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-03-01
coleção:Cell Reports
Assuntos:
Agrin
YAP/TAZ
hippo pathway
liver cancer
mechanotransduction
extracellular matrix
focal adhesions
integrins
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124717302395
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