Ex vivo modulation of intact tumor fragments with anti-PD-1 and anti-CTLA-4 influences the expansion and specificity of tumor-infiltrating lymphocytes

Checkpoint inhibition (CPI) therapy and adoptive cell therapy with autologous tumor-infiltrating lymphocytes (TIL-based ACT) are the two most effective immunotherapies for the treatment of metastatic melanoma. While CPI has been the dominating therapy in the past decade, TIL-based ACT is beneficial...

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Autors principals:	Thomas Morgan Hulen, Christina Friese, Nikolaj Pagh Kristensen, Joachim Stoltenborg Granhøj, Troels Holz Borch, Marlies J. W. Peeters, Marco Donia, Mads Hald Andersen, Sine Reker Hadrup, Inge Marie Svane, Özcan Met
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-06-01
Col·lecció:	Frontiers in Immunology
Matèries:	tumor-infiltrating lymphocyte (TIL) checkpoint inhibition metastatic melanoma cancer immunotherapy tumor microenevironment adoptive cell immunotherapy
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1180997/full
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