Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45^lowCD271⁺ Multipotential Stromal Cells (BM-MSCs): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation

Skeletal aging is associated with reduced proliferative potential of bone marrow (BM) multipotential stromal cells (MSCs). Recent data suggest the involvement of type 1 interferon (IFN1) signalling in hematopoietic stem cell (HSC) senescence. Considering that BM-HSCs and BM-MSCs share the same BM ni...

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Detalhes bibliográficos

Principais autores:	Payal Ganguly, Agata N. Burska, Charlotte L.M. Davis, Jehan J. El-Jawhari, Peter V. Giannoudis, Elena A. Jones
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-07-01
coleção:	Biomedicines
Assuntos:	aging mesenchymal stromal cells bone marrow type 1 interferon senescence
Acesso em linha:	https://www.mdpi.com/2227-9059/8/7/214
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