Large-scale analysis of de novo mutations identifies risk genes for female infertility characterized by oocyte and early embryo defects

Abstract Background Oocyte maturation arrest and early embryonic arrest are important reproductive phenotypes resulting in female infertility and cause the recurrent failure of assisted reproductive technology (ART). However, the genetic etiologies of these female infertility-related phenotypes are...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Qun Li, Lin Zhao, Yang Zeng, Yanping Kuang, Yichun Guan, Biaobang Chen, Shiru Xu, Bin Tang, Ling Wu, Xiaoyan Mao, Xiaoxi Sun, Juanzi Shi, Peng Xu, Feiyang Diao, Songguo Xue, Shihua Bao, Qingxia Meng, Ping Yuan, Wenjun Wang, Ning Ma, Di Song, Bei Xu, Jie Dong, Jian Mu, Zhihua Zhang, Huizhen Fan, Hao Gu, Qiaoli Li, Lin He, Li Jin, Lei Wang, Qing Sang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-04-01
Schriftenreihe:	Genome Biology
Schlagworte:	Female infertility De novo mutations Reproductive pathways TUBA4A Microtubule stability
Online-Zugang:	https://doi.org/10.1186/s13059-023-02894-0
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!