Synergistic Therapeutic Effects of Low Dose Decitabine and NY-ESO-1 Specific TCR-T Cells for the Colorectal Cancer With Microsatellite Stability

Patients of colorectal cancer (CRC) with microsatellite stability (MSS) show poor clinical response and little beneficial result from the immune-checkpoint inhibitors, due to the ‘cold’ tumor microenvironment. Meanwhile, decitabine can drive the ‘cold’ microenvironment towards ‘hot’ in multiple ways...

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Detalhes bibliográficos

Principais autores:	Ganjun Yu, Wenying Wang, Xiaobo He, Jia Xu, Rongrong Xu, Tao Wan, Yanfeng Wu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-06-01
Colecção:	Frontiers in Oncology
Assuntos:	decitabine T cell receptor engineered T cell synergistic therapy colorectal cancer microsatellite stability
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2022.895103/full
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