Optimized Digestion Conditions for Membrane Protein Footprinting and Mass Spectrometry Analysis

Integral membrane proteins (IMPs), which constitute 50–60% of drug targets, play essential roles in numerous biological processes but remain underrepresented in conventional bottom-up and structural proteomics owing to their hydrophobicity and resistance to proteolysis. Although advances in IMP prot...

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Hlavní autoři:	Ming Cheng, Xinzhu Li, Lin Bai, Weikai Li, Michael L. Gross
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2026-06-01
Edice:	Membranes
Témata:	membrane protein vitamin K epoxide reductase (VKOR) mass spectrometry protein footprinting filter-aided sample preparation (FASP) membrane protein digestion
On-line přístup:	https://www.mdpi.com/2077-0375/16/6/215
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