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Effects of CYP3A4*22 polymorphism on trough concentration of tacrolimus in kidney transplantation: a systematic review and meta-analysis

Purpose: Tacrolimus (Tac) is a widely used immunosuppressive agent in kidney transplantation. Cytochrome P450 (CYP), especially CYP3A4 enzymes are responsible for the metabolism of drugs. However, the correlation between plasma Tac concentration and CYP3A4*22 gene variants is controversial. This met...

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Principais autores: Jung Sun Kim, Sunyoung Shim, Jeong Yee, Kyung Hee Choi, Hye Sun Gwak
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-07-01
Serier:Frontiers in Pharmacology
Fag:
tacrolimus
CYP3A4*22
polymorphism
trough concentration
kidney transplantation
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2023.1201083/full
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