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Biasing AlphaFold2 to predict GPCRs and kinases with user-defined functional or structural properties

Determining the three-dimensional structure of proteins in their native functional states has been a longstanding challenge in structural biology. While integrative structural biology has been the most effective way to get a high-accuracy structure of different conformations and mechanistic insights...

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Hlavní autoři: Davide Sala, Peter W. Hildebrand, Jens Meiler
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2023-02-01
Edice:Frontiers in Molecular Biosciences
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On-line přístup:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1121962/full
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