Neutralizing antibodies targeting a novel epitope on envelope protein exhibited broad protection against flavivirus without risk of disease enhancement

Abstract Background Flavivirus causes many serious public health problems worldwide. However, licensed DENV vaccine has restrictions on its use, and there is currently no approved ZIKV vaccine. Development of a potent and safe flavivirus vaccine is urgently needed. As a previous study revealed the e...

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Hauptverfasser:	Li-Chen Yen, Hsin-Wei Chen, Chia-Lo Ho, Chang-Chi Lin, Yi-Ling Lin, Qiao-Wen Yang, Kuo-Chou Chiu, Shu-Pei Lien, Ren-Jye Lin, Ching-Len Liao
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-06-01
Schriftenreihe:	Journal of Biomedical Science
Schlagworte:	Japanese encephalitis virus Dengue virus Zika virus Flavivirus vaccine Neutralizing epitope Envelop protein domain II
Online-Zugang:	https://doi.org/10.1186/s12929-023-00938-y
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