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Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension

Summary: Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial hypertension. We identified a differential role of...

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Principais autores: Haiyang Tang, PhD, Kang Wu, MD, PhD, Jian Wang, MD, Sujana Vinjamuri, MD, MS, Yali Gu, MS, RN, Shanshan Song, MD, PhD, Ziyi Wang, MD, Qian Zhang, MD, Angela Balistrieri, Ramon J. Ayon, PhD, Franz Rischard, MD, Rebecca Vanderpool, PhD, Jiwang Chen, PhD, Guofei Zhou, PhD, Ankit A. Desai, MD, Stephen M. Black, PhD, Joe G.N. Garcia, MD, Jason X.-J. Yuan, MD, PhD, Ayako Makino, PhD
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018-12-01
coleção:JACC: Basic to Translational Science
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2452302X18302316
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