The LEF1–LAG3 axis regulates CD4+ T cell function during Plasmodium yoelii NSM infection

Abstract Background CD4⁺ T cells are pivotal in coordinating anti-malarial immunity, while co-inhibitory receptors such as LAG3 critically regulate their function. However, the phenotype of LAG3⁺CD4⁺ T cells during Plasmodium infection and the upstream molecular mechanisms regulating LAG3 expression...

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Autori principali:	Wenbo Peng, Guikuan Liang, Keyu Lu, Feng Mo, Xiongyu Xie, Mingjie Chen, Haiwen Yuan, Lixin Luo, Xingyue Wang, Long Xu, Haixia Wei, Lu Li, Shan Zhao, Hongyan Xie, Xingfei Pan, Jun Huang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-05-01
Serie:	Parasites & Vectors
Soggetti:	Malaria CD4⁺ T cells LAG3 LEF1
Accesso online:	https://doi.org/10.1186/s13071-026-07439-5
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