Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis

Abstract Background Cerebral ischemia-reperfusion injury (CIRI) refers to a secondary brain injury that can occur when the blood supply to the ischemic brain tissue is restored. However, the mechanism underlying such injury remains elusive. Methods The 150 male C57 mice underwent middle cerebral art...

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Autores principales:	Xue Zeng, Yun-Dong Zhang, Rui-Yan Ma, Yuan-Jing Chen, Xin-Ming Xiang, Dong-Yao Hou, Xue-Han Li, He Huang, Tao Li, Chen-Yang Duan
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	KeAi Communications Co., Ltd. 2022-05-01
Colección:	Military Medical Research
Materias:	Cerebral ischemia-reperfusion (CIRI) Oxygen–glucose deprivation/reoxygenation (OGD/R) Drp1 p62 LC3 II/I Reactive oxygen species (ROS)
Acceso en línea:	https://doi.org/10.1186/s40779-022-00383-2
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