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Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks

Here, using mouse squamous cell carcinoma cells, we report a completely new function for the autophagy protein Ambra1 as the first described ‘spatial rheostat’ controlling the Src/FAK pathway. Ambra1 regulates the targeting of active phospho-Src away from focal adhesions into autophagic structures t...

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Principais autores: Christina Schoenherr, Adam Byron, Emma Sandilands, Ketevan Paliashvili, George S Baillie, Amaya Garcia-Munoz, Cristina Valacca, Francesco Cecconi, Bryan Serrels, Margaret C Frame
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2017-03-01
Serier:eLife
Fag:
Src
FAK
Ambra1
IFITM3
invasion
trafficking
Online adgang:https://elifesciences.org/articles/23172
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