Dual PDE4/10A inhibition restores CREB1 function and enhances neuronal resilience in models of alzheimer's disease

Abstract Background Alzheimer’s disease (AD) involves cognitive decline, amyloid-beta (Aβ) accumulation, tau hyperphosphorylation, and neuroinflammation. CREB1, a key transcription factor for memory, is downregulated in AD, contributing to disease progression. Phosphodiesterases 4 and 10 (PDE4 and P...

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Autors principals:	Xiaoli Rong, Xia Yao, Haohui Fang, Johns Saji, Yu Qian, Jia-Xuan Gu, Meng-Yuan Yang, Peng Wei, Cai-Rui Liu, Bin Chen, Pian-Pian Zhao, Ching-Lung Cheung, Lin Bo, Hou-Feng Zheng
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-10-01
Col·lecció:	Alzheimer’s Research & Therapy
Matèries:	Alzheimer's disease PDE4/PDE10A inhibition cAMP-PKA-CREB signaling Neuronal resilience
Accés en línia:	https://doi.org/10.1186/s13195-025-01869-6
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