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Generation of a Hutchinson–Gilford progeria syndrome monkey model by base editing

Abstract Many human genetic diseases, including Hutchinson-Gilford progeria syndrome (HGPS), are caused by single point mutations. HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene. Base editors (BEs) composed of a cytidine deamina...

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Збережено в:
Автори: Fang Wang, Weiqi Zhang, Qiaoyan Yang, Yu Kang, Yanling Fan, Jingkuan Wei, Zunpeng Liu, Shaoxing Dai, Hao Li, Zifan Li, Lizhu Xu, Chu Chu, Jing Qu, Chenyang Si, Weizhi Ji, Guang-Hui Liu, Chengzu Long, Yuyu Niu
Формат: Artigo
Мова:Inglês
Опубліковано: Oxford University Press 2020-07-01
Серія:Protein & Cell
Предмети:
base editing
non-human primate
HGPS
Онлайн доступ:https://doi.org/10.1007/s13238-020-00740-8
Теги: Додати тег
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