A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites

Picornaviruses use modular RNA domains in their internal ribosome entry sites (IRESs) for translation through non-canonical, cap-independent mechanisms. Here the authors report the crystal structure of domain V from the IRES of hepatitis A virus (HAV) ssRNA genome, suggesting that the functional hom...

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Autors principals:	Deepak Koirala, Yaming Shao, Yelena Koldobskaya, James R. Fuller, Andrew M. Watkins, Sandip A. Shelke, Evgeny V. Pilipenko, Rhiju Das, Phoebe A. Rice, Joseph A. Piccirilli
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2019-08-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-019-11585-z
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