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Sickle cell mice exhibit mechanical allodynia and enhanced responsiveness in light touch cutaneous mechanoreceptors

<p>Abstract</p> <p>Background</p> <p>Sickle cell disease (SCD) is associated with both acute vaso-occlusive painful events as well as chronic pain syndromes, including heightened sensitivity to touch. We have previously shown that mice with severe SCD (HbSS mice; express 100% human sickle hemoglobin...

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Main Authors: Garrison Sheldon R, Kramer Audra A, Gerges Nashaat Z, Hillery Cheryl A, Stucky Cheryl L
Format: Artigo
Language:Inglês
Published: SAGE Publishing 2012-09-01
Series:Molecular Pain
Subjects:
Primary afferents
Allodynia
Pain
Nociception
Anxiety
Open field test
Online Access:http://www.molecularpain.com/content/8/1/62
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