Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses

Abstract Neuro-inflammation has been shown to play a critical role in the development of depression. Beta-hydroxybutyrate (BHB) is a ketone body and has recently been reported to exert anti-inflammatory effects via inhibition of NLRP3 inflammasome. Here, we investigated the potential antidepressant...

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Główni autorzy:	Takehiko Yamanashi, Masaaki Iwata, Naho Kamiya, Kyohei Tsunetomi, Naofumi Kajitani, Nodoka Wada, Takahiro Iitsuka, Takahira Yamauchi, Akihiko Miura, Shenghong Pu, Yukihiko Shirayama, Ken Watanabe, Ronald S. Duman, Koichi Kaneko
Format:	Artigo
Język:	Inglês
Wydane:	Nature Portfolio 2017-08-01
Seria:	Scientific Reports
Dostęp online:	https://doi.org/10.1038/s41598-017-08055-1
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