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Development of mucoadhesive in-situ nasal gel formulation for enhanced bioavailability and efficacy of rizatriptan in migraine treatment

This research article focuses on the development of an in-situ nasal gel formulation for the antimigraine agent, Rizatriptan (RZT), to enhance its bioavailability and efficacy in treating migraine. The aim of the study was to overcome the challenges of rapid mucociliary clearance. Carbopol 934P (1–2...

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Principais autores: Kaushik Suhagiya, Chetan H. Borkhataria, Sumit Gohil, Ravi A. Manek, Kalpesh A. Patel, Nilesh K. Patel, Dhaval V. Patel
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-12-01
Serier:Results in Chemistry
Fag:
Rizatriptan
Mucoadhesive
In-situ nasal gel
Carbopol 934P
HPMC K4M
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211715623002497
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