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Harnessing multivalency and FcγRIIB engagement to augment anti-CD27 immunotherapy

Abstract Despite significant clinical progress, checkpoint blockade remains limited by variable response rates, resistance, and toxicity. Activating costimulatory receptors offers a promising alternative to enhance anti-tumor immunity. However, there is insufficient understanding of how to mimic phy...

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Príomhchruthaitheoirí: Marcus A. Widdess, Anastasia Pakidi, Hannah J. Metcalfe, H. T. Claude Chan, Tatyana Inzhelevskaya, Chris A. Penfold, C. Ian Mockridge, Steven G. Booth, Sonya James, Sean H. Lim, Stephen A. Beers, Mark S. Cragg, Aymen Al-Shamkhani
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Nature Portfolio 2025-12-01
Sraith:Nature Communications
Rochtain ar líne:https://doi.org/10.1038/s41467-025-67882-3
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