Silencing SFRP1 in bone mesenchymal stem cells alleviates pediatric B-ALL-driven bone loss by activating Wnt/β-catenin signaling

Background: Bone loss is the most common skeletal complication of childhood acute lymphoblastic leukemia (ALL) and seriously affects the long-term survival quality of children. However, the mechanisms behind bone loss are complicated and need to be elucidated. This study seeks to examine the princip...

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Autori principali:	Mengxia Li, Xu He, Xingzhi Liu, Mimi Chen, Qian Sun, Ronghui Yu, Wendong Liu, Qi Wang, Guanghao Su, Qin Shi, Xiaodong Wang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-03-01
Serie:	Journal of Orthopaedic Translation
Soggetti:	Bone loss Mesenchymal stem cells Pediatric acute lymphoblastic leukemia SFRP1 shSFRP1@Lipo-E7
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2214031X26000264
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