Improving butenyl-spinosyn production in Saccharopolyspora pogona through combination of metabolic engineering and medium optimization

Butenyl-spinosyn is a high-quality biological insecticide produced by Saccharopolyspora pogona that effectively targets a broad range of insect pests. However, the large-scale production of this insecticide is hindered by its low yield. Herein, based on prior comparative genomic analysis, five mutat...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Xueli Zhao, Haisong Lu, Sen Peng, Haifeng Hang, Waleed Aldahmash, Muath Q. Al-Ghadi, Weihua Tang, Jiang Pei, Wan Xun, Meijin Guo, Ali Mohsin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2025-04-01
Schriftenreihe:	Frontiers in Microbiology
Schlagworte:	Saccharopolyspora pogona butenyl-spinosyn genomics-based metabolic engineering medium optimization targeted metabolomic analysis
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fmicb.2025.1561042/full
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