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Histone 2B-GFP Label-Retaining Prostate Luminal Cells Possess Progenitor Cell Properties and Are Intrinsically Resistant to Castration

Summary: The existence of slow-cycling luminal cells in the prostate has been suggested, but their identity and functional properties remain unknown. Using a bigenic mouse model to earmark, isolate, and characterize the quiescent stem-like cells, we identify a label-retaining cell (LRC) population i...

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Huvudupphov: Dingxiao Zhang, Collene Jeter, Shuai Gong, Amanda Tracz, Yue Lu, Jianjun Shen, Dean G. Tang
Materialtyp: Artigo
Språk:Inglês
Utgiven: Elsevier 2018-01-01
Serie:Stem Cell Reports
Ämnen:
prostate stem cells
luminal progenitors
label-retaining cells
quiescence
prostate cancer
prostate
Länkar:http://www.sciencedirect.com/science/article/pii/S2213671117305234
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